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Visible Light‐Induced Umpolung Synthesis of 3,3‐Disubstituted Oxindoles via the Substrate‐Photosensitive Strategy

Year: 2024

Type: article

Abstract: 3,3-disubstituted oxindoles, forming the core of extensive bioactive natural products and drugs, attract tremendous efforts to develop efficient methods for their preparation. Here, a substrate-photosensitive strategy for the selective synthesis of 3-substituted 3-aminooxindoles from N-Boc isatin ketimines irradiated by visible light was reported with high yields and broad functional group compatibility.

Source: Chinese Journal of Chemistry

DOI: 10.1002/cjoc.202400973

Authors: Jingjing Yang, Tingting Wang, Benhui Sui, Hongyu Wang, Bo Tang

Institutions: Ocean University of China, Shandong Normal University, Qingdao National Laboratory for Marine Science and Technology, Laoshan Laboratory

Language: English

Topic: Radical Photochemical Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,140

Funder: National Natural Science Foundation of China