Work

The Effects of Different Treatments on Serum Trace Element Levels in Dogs with Heart Failure

Year: 2024

Type: article

Abstract: The prognostic and diagnostic role of some trace elements in heart diseases has been demonstrated. In this study, the effects of min. 30-day and min. 120-day treatment with pimobendan, enalapril, and furosemide, as monotherapy and in combination, on serum trace element levels in dogs with heart failure were evaluated. A total of 107 dogs were treated with pimobendan or enalapril as monotherapy and pimobendan + enalapril (PE), enalapril + furosemide (EF), or pimobendan + enalapril + furosemide (PEF) as combination therapy for a min. of 30 and 120 days. Serum copper (Cu), zinc (Zn), iron (Fe), cobalt (Co), magnesium (Mg), manganese (Mn), selenium (Se), and chromium (Cr) were measured by an inductive coupled plasma optical emission spectroscopy device. Mean serum Mg in dogs treated with pimobendan for a min. of 120 days was significantly lower than that for a min. of 30 days (p < 0.05). In dogs using the PEF combination, mean serum Fe was significantly higher in the min. 120-day treatment group than in the min. 30-day treatment group (p < 0.01). No significant difference was observed in mean serum Cu, Zn, Co, Mn, Se, or Cr between the treatment groups and the time periods (p > 0.05). The short- and long-term use of pimobendan, enalapril, furosemide, and their combinations may cause changes in mean serum Mg and Fe in dogs with heart failure.

Source: Animals

DOI: 10.3390/ani14233390

Authors: Bengü Bilgiç, Duygu Tarhan, Mehmet Erman Or

Institutions: Istanbul University-Cerrahpaşa, Istanbul University, Bahçeşehir University

Language: English

Topic: Trace Elements in Health

Subfield: Nutrition and Dietetics

Field: Nursing

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,728