A 10-year comparative study of factors for allergic asthma and/or rhinitis in two cross-sectional surveys
Year: 2024
Type: article
Study design: Observational Study
Abstract: BACKGROUND: The allergenic relevance of the living environment changes over the last decades is largely unknown. OBJECTIVE: We aimed to compare the factors associated with asthma and/or rhinitis between 2008 and 2018. METHODS: We assessed two nationally representative cross-sectional datasets in 2008 and 2018. Within the rigorous protocol, questionnaire and serum IgE measurement were conducted in 2322 and 2353 patients with allergic asthma (A) and/or rhinitis (R) respectively. Multivariate logistic regression analysis was used to examine the effect of different factors on sensitization. RESULTS: The prevalence of sensitization increased in rhinitis alone (A-R+, 63% in 2008 vs. 67.7% in 2018, P = 0.039) and asthma with rhinitis (A+R+, 70.6% vs. 75.1%, P = 0.014). The common factors for sensitization were male sex, using mattress and air conditioner, family history of rhinitis, building age > 30 years, and meat consumption. Compared with 2008, secondhand smoke was an additional risk factor for A+R- (odds ratio [OR] 2.17, 95% confidence interval [CI] 1.18-7.01) and A+R+ (OR 1.72, 95%CI 1.03-3.14), and the odds of farmland or forest for pollen and mold sensitization were higher in 2018 (OR 3.61, 95%CI 2.79-4.66, and OR 1.86, 95%CI 1.34-2.58). Eating fish was inversely associated with A-R+ (OR 0.68, 95%CI 0.52-0.91, P < 0.01), while older age also showed an inverse relationship with sensitization. The OR of age 25-44 years was higher in 2018. CONCLUSIONS: Repeated surveys showed variations in the factors affecting allergic asthma and/or rhinitis. The variable factors included age of 25-44 years, secondhand smoke, farmland, forest, and fish consumption.
Authors: Wanjun Wang, Jianhong Wang, Yan Jiang, Xiaoli Han, Guolin Tan, Jianjun Chen, Qianhui Qiu, Huabin Li, Jing Li
Institutions: First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, Affiliated Hospital of Qingdao University, Hebei General Hospital, Third Xiangya Hospital, Wuhan Union Hospital, Zhujiang Hospital, Southern Medical University, Fudan University, Eye & ENT Hospital of Fudan University
Language: English
Subfield: Immunology and Allergy
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: Wenzhou Medical University, Guangdong Provincial Hospital of Traditional Chinese Medicine, Tongji University, Ningbo University, Tianjin University, Zhengzhou University, Henan University, Zhejiang University, Xinjiang Medical University, Sichuan University, Shanghai Jiao Tong University, Nanjing Medical University, Soochow University, Shanxi Medical University, Xiamen University, Shandong First Medical University, First Affiliated Hospital of Zhengzhou University, Guangdong Provincial People's Hospital, Ruijin Hospital, Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, West China Hospital, Sichuan University
Award: G6877718496
OpenAlex ID: W4404707494