Effect of high sensitivity C-reactive protein on uric acid-related cardiometabolic risk in patients with coronary artery disease—a large multicenter prospective study
Year: 2024
Type: article
Study design: Observational Study
Abstract: Although serum uric acid (SUA) is a risk factor for cardiometabolic outcome, but it remains unclear which patients with coronary artery disease (CAD) benefit the most from SUA lowering therapy (ULT). The association of SUA level, systemic inflammation and cardiometabolic risk is still unclear. The current study is aimed to examine whether SUA-associated cardiometabolic risk is modulated by systemic inflammation in CAD patients. A total of 16,598 CAD patients with baseline high-sensitivity C-Reactive Protein (hsCRP) and SUA available were included. Baseline and follow-up data were collected. The primary endpoint was major adverse cardiovascular and cerebrovascular events (MACCE), including death, myocardial infarction and stroke. In patients with hsCRP ≥ 2 mg/L, increasing quintiles of SUA were significantly associated with increased rates of 2-year MACCE (adjusted p < 0.001 for trend, p = 0.037 for interaction). Each unit increase in SUA levels was associated with a 11.3% increased risk of MACCE (adjusted p < 0.001, p = 0.002 for interaction). However, in patients with hsCRP < 2 mg/L, increasing quintiles of SUA were not associated with increased MACCE (adjusted p = 0.120). Elevated SUA levels are related to MACCE when hsCRP levels are 2 mg/L or more but not less than 2 mg/L. This finding suggests a potential benefit of combined ULT and anti-inflammation therapy in patients with hyperuricemia and greater systemic inflammation.
Source: Scientific Reports
Institutions: Chinese Academy of Medical Sciences & Peking Union Medical College, Fu Wai Hospital, First Hospital of Lanzhou University, General Hospital of Shenyang Military Region, Peking Union Medical College Hospital, Peking University Third Hospital, First Affiliated Hospital Zhejiang University, Xinxiang Central Hospital, Guangdong Provincial People's Hospital, First Hospital of Qinhuangdao
Language: English
Subfield: Nephrology
Field: Medicine
Domain: Health Sciences
Open Access status: gold
Estimated APC paid: $2,590
Funders: National Children's Research Centre, National Natural Science Foundation of China, Chinese Academy of Medical Sciences, Natural Science Foundation for Young Scientists of Shanxi Province, Young Scientists Fund, Fuwai Hospital, Chinese Academy of Medical Sciences, National Key Research and Development Program of China
OpenAlex ID: W4404716843