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Discovery of UCB9386: A Potent, Selective, and Brain-Penetrant Nuak1 Inhibitor Suitable for In Vivo Pharmacological Studies

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Year: 2024
Type: article
Source: Journal of Medicinal Chemistry
DOI: 10.1021/acs.jmedchem.4c01237
Authors: Karine G. Poullennec, Eric Jnoff, Jan Abendroth, Naresh Bhuma, Mark Calmiano, Laurent Calmus, Alvaro Cardenas, Jean-Philippe Courade, Claude Delatour, Adrian Hall, Teresa de Haro, Silvia L. Delker, Thierry Demaude, Nilesh Gaikwad, Dnyaneshwar Ghavate, Atul R. Gholap, Magdalena Kierkowicz, Régis Le Mestre, Nathalie Van Hijfte, Simon Verheijden, Katerina Vernerova, Veerle De Wever, Nivrutti Waghmode
Institutions: Illumina (United Kingdom), BenevolentAI (United Kingdom), Urban College of Boston, UCB Pharma (United Kingdom), Janssen (Belgium)
Language: English

Topic: Computational Drug Discovery Methods
Subfield: Computational Theory and Mathematics
Field: Computer Science
Domain: Physical Sciences
SDG: Good health and well-being

Open Access status: closed

Funder: UCB
OpenAlex ID: W4404717663
FWCI: 0.976
Cites: 79
Cited by: 5
Related to: 10
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