Work

Synthesis of the 1,5-disubstituted tetrazole-methanesulfonylindole hybrid system via high-order multicomponent reaction

Year: 2024

Type: article

Abstract: A series of 1,5-disubstituted tetrazole-indole hybrids were synthesized via a high-order multicomponent reaction consisting of an Ugi-azide/Pd/Cu-catalyzed hetero-annulation cascade sequence. This operationally simple one-pot protocol allowed high bond-forming efficiency and creating six new bonds (two C-C, three C-N, and one N-N). Additionally, the products were evaluated against breast cancer MCF-7 cells, finding moderate activity in the compounds substituted with fluorine and chlorine.

Source: Beilstein Journal of Organic Chemistry

DOI: 10.3762/bjoc.20.256

Authors: Cesia M Aguilar-Morales, América A Frías-López, Nadia V Emilio-Velázquez, Alejandro Islas-Jácome, Angelica Judith Granados-López, Jorge Gustavo Araujo-Huitrado, Yamilé López-Hernández, Hiram Hernández-López, Luis Chacón-García, Jesús Adrián López, Carlos Jesús Cortés-García

Institutions: Universidad Michoacana de San Nicolás de Hidalgo, Instituto de Investigaciones Químico Biológicas, Universidad Autónoma Metropolitana, Universidad Autónoma de Zacatecas "Francisco García Salinas", Secretaría de Ciencia, Humanidades, Tecnología e Innovación

Language: English

Topic: Multicomponent Synthesis of Heterocycles

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: diamond

Funder: Universidad Michoacana de San Nicolás de Hidalgo

OpenAlex ID: W4404723483

FWCI: 0.424

Cites: 50

Cited by: 3

Related to: 10