Wuling capsule combined with sertraline in the therapy of anxiety and depression with insomnia in adolescents
Year: 2024
Type: article
Study designs: Randomized Controlled Trial, Clinical Trial
Abstract: BACKGROUND The treatment of adolescent patients with anxiety, depression and insomnia is challenging, and there is no ideal treatment method. AIM To evaluate the clinical efficacy of Wuling capsule combined with sertraline in the treatment of adolescent anxiety, depression and insomnia. METHODS Eighty adolescent patients with anxiety, depression with insomnia who were admitted to our hospital from April 1, 2022 to March 30, 2024. And the subjects were randomly classified into the control group (n = 40) and the observational group (n = 40). The control group was treated with a combination of sertraline and placebo. The observation group was treated with Wuling capsule in addition to sertraline. The two groups were cured continuously for 8 weeks. Insomnia severity index (ISI), Hamilton Anxiety Scale (HAMA) and Hamilton Depression Scale (HAMD) were used to evaluate the clinical symptoms before treatment and at 2, 4, 6 and 8 weeks after treatment. The Treatment Emergent Symptom Scale (TESS) was used to evaluate adverse reactions during treatment. RESULTS There was no obvious difference in HAMD, HAMA and ISI scores between the two groups before treatment (P > 0.05). After treatment, the HAMD, HAMA and ISI scores of patients in both groups decreased compared with before treatment, and HAMD, HAMA and ISI scores of patients in the observation group were remarkedly lower than those in the control group at each time point after treatment (P < 0.05). Compared with the control group, the TESS score of the study group were sharply lower (t = 18.239, P < 0.001). CONCLUSION Wuling capsule can further alleviate the insomnia symptoms of adolescents with anxiety and depression, and the efficacy and safety are high. It is recommended to promote the application.
Source: World Journal of Psychiatry
Authors: Li-Li Duo, Gao-Feng Rao
Language: English
Topic: Sleep and related disorders
Subfield: Experimental and Cognitive Psychology
Field: Psychology
Domain: Social Sciences
Open Access status: diamond
Funders: John D. and Catherine T. MacArthur Foundation, Bristol-Myers Squibb, Eli Lilly and Company, Pfizer, GlaxoSmithKline, European Commission, South African Medical Research Council, Public Health Agency, Ulster University, ZonMw, Generalitat de Catalunya, Departament d'Innovació, Universitats i Empresa, Generalitat de Catalunya, Consejo Nacional de Ciencia y Tecnología, Ministerio de Sanidad, Servicios Sociales e Igualdad, Koning Boudewijnstichting, Pfizer Foundation, Pan American Health Organization, Plan Nacional sobre Drogas, Medical Research Council, Instituto de Salud Carlos III, European Regional Development Fund, Division of Research Capacity Development, National Institute of Mental Health, Fogarty International Center
Awards: G1037158725, G106448529, G1157590053, G1212575712, G1226586044, G1383203395, G1550703150, G2237026874, G2635957603, Predicting Internet-Based Treatment Response for Major Depressive Disorder, PROMIS.es Salud Mental:calibración y validación de un instrumento informatizado de evaluación de resultados percibidos por los pacientes para diagnóstico y monitorización en Salud Mental, G3087164589, G3288897321, G3649151923, G3658001182, G401567910, G4076321871, G4162927379, G4343333309, G4423770871, G5103078189, G5279905574, G578575042, G6467163680, G6629244973, G6667095330, G7284921876, G7433974870, G7557889688, G7910637792, G8309976149, UNIVERSAL: Universidad y salud mental. Modelos predictivos de ideación y conducta suicida en estudiantes universitarios españoles, G851565850, Lebanon-Epidemiology: The NCS Replication Study, G8808417261
OpenAlex ID: W4404730604