Work

Dedifferentiated recurrent liposarcoma of the uterine corpus: A case report and literature review

Year: 2024

Type: article

Abstract: Liposarcoma of the uterine corpus represents an exceptionally rare tumor, with few cases documented in the literature, underscoring its unique histopathologic characteristics and management challenges. This case describes the clinical management of a 57-year-old patient with well-differentiated liposarcoma of the uterine corpus who presented with a three-month history of abdominal pain and distension. She underwent an abdominal hysterectomy followed by chemotherapy but experienced local recurrence in the mesentery and retroperitoneum after 21 months. Tumor resection was performed again, followed by chemotherapy, but the patient experienced a second recurrence 15 months later, involving the small intestine, vaginal stump, and ureter, with evidence of dedifferentiated liposarcoma. A third surgical resection was carried out without administering chemotherapy and the patient remained asymptomatic at follow-up appointments every 3 months for a year. This case highlights the importance of acknowledging the aggressive nature of recurrent liposarcoma, especially its transition into dedifferentiated liposarcoma, and the need for tailored management strategies. • This case illustrates recurrent dedifferentiated liposarcoma of the uterine corpus, progressing from the peritoneal to retroperitoneal space. • Dedifferentiation of liposarcoma, with MDM2 and CDK4 gene amplification, leads to more aggressive tumor behavior. • There is no standard care for primary uterine liposarcoma, resulting in varying management strategies. • The patient was treated with surgery and chemotherapy, combining doxorubicin/cyclophosphamide and ifosfamide/doxorubicin for a unique approach.

Source: Case Reports in Women s Health

DOI: 10.1016/j.crwh.2024.e00670

Authors: Sana Mushtaq, Muhammad Arslan Ul Hassan, Yan Li, Ikran Abdi, Aqsa Ahmad, HaiNing Li

Institutions: Ningxia Medical University, Ningxia Medical University General Hospital

Language: English

Topic: Sarcoma Diagnosis and Treatment

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $860