Work

Novel administration strategies for tissue-specific delivery of extracellular vesicles

Year: 2024

Type: article

Abstract: Extracellular vesicles (EVs) are nanoparticles released by cells with bilayer lipid membranes that have been demonstrated to regulate biological activities. The potential of EVs as a novel therapeutic or drug delivery platform has already been identified in emerging research. The therapeutic efficacy of EVs is contingent upon the quantity of EVs internalized by target cells, which necessitates the enhanced retention of EVs in target organs. Accordingly, various novel administration strategies for the targeted delivery of therapeutic EVs into specific tissues were developed. This review presents a comprehensive overview of the latest developments in EV delivery routes for brain-, heart-, lung-, skin-, eye-, and gastrointestinal tract-specific applications. We believe that the emergence of innovative EV administration strategies will contribute to the future clinical trials and eventual applicability of EV-based therapeutics.

Source: Extracellular Vesicle

DOI: 10.1016/j.vesic.2024.100057

Authors: Junyao Deng, Qishan Li, Fei Wang

Institutions: Dongguan People’s Hospital, Southern Medical University

Language: English

Topic: Extracellular vesicles in disease

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,800