Space manufacturing of a bone tissue destined for patients on Earth?
Year: 2024
Type: article
Abstract: Space exploration is perhaps one of the most difficult tasks ever undertaken since the emergence of humankind. The International Space Station is a unique platform for advanced technology research that is not possible anywhere else. Tissue engineering in outer space, where state of the gravity can be ‘turned off’ or ‘turned on’ in the case of application of centrifuges, is a new research field with high-value goals. The microgravity conditions allow to design novel biomaterials that cannot be produced on Earth but benefit the Earth civilisation. Developing and manufacturing a biomaterial to address a space-based challenge may lead to novel biomaterials that will find important applications in medicine on Earth and/or for long-duration space missions. Today, there are only a handful of emerging biomaterials that have been tested in space, none of which have been used for their eventual function. This paper presents advances in space technology via 3D magnetic assembly: the development of synthetic bone graft constructs aboard the International Space Station during expeditions 60/61 with clear evidence of the materials' functioning in preclinical (animal) tests on Earth. The results indicate high osteoconductivity and ultimately a good rate of tissue formation by the bone grafts prepared in space. The graphical abstract was generated after a reading of this manuscript by a neural network. The Dream algorithm was used based on a CLIP-guided approach. CLIP is an open-source neural network (a freely available algorithm that learns about patterns in data) created by research lab OpenAI ( https://openai.com/ ). To generate this artwork, the Dream model started with a randomly generated vector: a mathematical representation of an image.
Source: Biomedical Technology
Authors: Vladimir S. Komlev, Vladislav A. Parfenov, Pavel A. Karalkin, Stanislav V. Petrov, Frederico D.A.S. Pereira, Elizaveta V. Koudan, Aleksandr A. Levin, Margarita A. Goldberg, Alexander Yu. Fedotov, Igor V. Smirnov, Andrey D. Kaprin, Natalia S. Sergeeva, Irina K. Sviridova, Valentina A. Kirsanova, Suraja A. Akhmedova, Georgy V. Mamin, Marat R. Gafurov, Alexey N. Gurin, Yusef D. Khesuani, Yury M. Urlichich
Institutions: Russian Academy of Sciences, Lomonosov Moscow State University, Baikov Institute of Metallurgy and Materials Science, Sechenov University, Ministry of Health of the Russian Federation, P.A. Hertzen Moscow Oncology Research Institute, 3D Bioprinting Solutions (Russia), Kazan Federal University
Language: English
Subfield: Biomedical Engineering
Field: Engineering
Domain: Physical Sciences
Open Access status: diamond
OpenAlex ID: W4404738413