Work

Microfluidics-generated PLA nanoparticles: impact of purification method on macrophage interactions, anti-inflammatory effects, biodistribution, and protein corona formation

Year: 2024

Type: article

Abstract: biodistribution studies suggested purification method-dependent alterations, which were correlated with protein corona profiles. This study underscores the potential of TFF, combined with microfluidics, as an efficient and high-yield purification method for NPs, and reveals the need for extensive confirmation of NP biological activity alongside physicochemical properties when developing NP therapeutics at-scale.

Source: RSC Pharmaceutics

DOI: 10.1039/d4pm00233d

Authors: Jacob R. Shaw, Radha Vaidya, Fanny Xu, Shruti Dharmaraj, Ryan M. Pearson

Institutions: University of Maryland, Baltimore, University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center

Language: English

Topic: Nanoparticle-Based Drug Delivery

Subfield: Biomaterials

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: National Institutes of Health, National Cancer Institute, National Institute of General Medical Sciences