Work

Real-time radiation beam imaging on an MR linear accelerator using quantitative T1 mapping

Year: 2024

Type: conference-paper

Abstract: Motivation: Direct imaging of radiation beam effects could enable more accurate dosimetry and in vivo dose verification. Goal(s): Our goal was to detect immediate changes in T1 relaxation due to water radiolysis induced oxygen depletion. Approach: We used dynamic T1 mapping on an MR-Linac to simultaneously irradiate and image water phantoms. Results: We observed real-time changes in T1 with a T1/Dose slope of 0.71 ms/Gy. The current sensitivity limit was estimated to be 3 Gy for a 10 min scan. Three-dimensional spatial patterns in T1 were consistent with the predicted dose profile. Impact: Real-time visualization of radiation beam effects using quantitative T1 mapping may enable new radiation dosimetry methods. This study may lead to volumetric in vivo dose verification and imaging of transient oxygen depletion in high dose rate (“FLASH”) radiotherapy.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2024/1309

Authors: Brandon Tran, Liam Lawrence, Shawn Binda, Brige Chugh, Angus Lau

Language: English

Topic: Advanced Radiotherapy Techniques

Subfield: Radiation

Field: Physics and Astronomy

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404744679

FWCI: 3.235

Cites:

Cited by: 1

Related to: 10