Work

Quantitative multi-parametric mapping of human subcortex at ultrahigh field

Year: 2024

Type: conference-paper

Abstract: Motivation: Many neurodegenerative diseases affect subcortical nuclei early. Quantitative MRI (qMRI) offers a unique non-invasive tool for detection of neurodegeneration at its early stage, paving the way for development of potential therapies. Goal(s): Ultra-high resolution multi-modal cartography of human subcortex capable of detecting subtle longitudinal changes in macro- and microstructure of subcortical nuclei. Approach: We combined high resolution multi-parametric mapping using 7T, pTx and advanced reconstruction with automated segmentation of subcortical structures. Performance was tested across two sites. Results: While qMRI repeatability varied strongly by structure, automated parcellation was highly repeatable, making the protocol a promising candidate for further studies. Impact: We present a method for multi-contrast quantification of subcortical microstructure. Our high-resolution MRI acquisition and analysis protocol aims to enable longitudinal multi-center studies to detect subcortical neurodegeneration at its early stage.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2024/3714

Authors: Kerrin Pine, Mikhail Zubkov, Pierre-Louis Bazin, Gábor Perlaki, Luke Edwards, Anneke Alkemade, Gilles Vandewalle, Evgeniya Kirilina, Nikolaus Weiskopf

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404745503

FWCI:

Cites:

Cited by:

Related to: 10