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Associations of circulating T-cell subsets with carotid artery stiffness: the multiethnic study of atherosclerosis

Year: 2024
Type: article
Study design: Observational Study
Abstract: Background: Arterial stiffness measured by total pulse wave velocity (T-PWV) is associated with increased risk of multiple age-related diseases. T-PWV can be described by structural (S-PWV) and load-dependent (LD-PWV) arterial stiffening. T-cells have been associated with arterial remodeling, blood pressure, and arterial stiffness in humans and animals; however, it is unknown whether T-cells are related to S-PWV or LD-PWV. Therefore, we evaluated the cross-sectional associations of peripheral T-cell subpopulations with T-PWV, S-PWV, and LD-PWV stiffness. Methods: Peripheral blood T-cells were characterized using flow cytometry and the carotid artery was measured using B-mode ultrasound to calculate T-PWV at the baseline examination in a subset of the Multi-Ethnic Study of Atherosclerosis (MESA, n=1,984). A participant-specific exponential model was used to calculate S-PWV and LD-PWV based on elastic modulus and blood pressure gradients. The associations between five primary (p-significance<0.01) and twenty-five exploratory (p-significance<0.05) immune cell subpopulations, per 1-SD increment, and arterial stiffness measures were assessed using adjusted, linear regressions. Results: T-cells were associated with higher LD-PWV (β=0.04 m/s, p<0.01) after adjusting for co-variates. For the exploratory analysis, T-cell subpopulations that commonly shift with aging towards memory and differentiated/immunosenescent phenotypes were associated with greater T-PWV, S-PWV, and LD-PWV after adjusting for co-variates. Conclusions: In this cross-sectional study, several T-cell subpopulations commonly associated with aging were related with measures of arterial stiffness. Longitudinal studies that examine changes in T-cell subpopulations and measures of arterial stiffness are warranted.
DOI: 10.1152/ajpheart.00649.2024
Authors: Theodore M. DeConne, Petra Buzkova, Ryan Pewowaruk, Joseph A. Delaney, Bruce M. Psaty, Russell P. Tracy, Margaret F. Doyle, Colleen M. Sitlani, Alan L. Landay, Sally A. Huber, Timothy M. Hughes, Alain G. Bertoni, Adam D. Gepner, Nels C. Olson, Jingzhong Ding
Institutions: Wake Forest University Health Sciences, Wake Forest University, University of Washington, University of Vermont, University of Vermont Medical Center, The University of Texas Medical Branch at Galveston, University of Wisconsin–Madison, William S. Middleton Memorial Veterans Hospital
Language: English
Field: Medicine
Open Access status: hybrid
Awards: G1261793039, MESA, G1276754516, G1409423729, G1539384734, G1640378483, G1686417863, G1803853571, G2144938473, G22458031, G2262782284, MESA, G2553531566, G2580996367, MESA, G2837638605, G290884426, G291913881, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY--EBCT READING, G3570589137, G3647016462, G3687594596, G3762349130, MESA, G399481048, TITLE: MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA), G4512137732, G4563812999, G4659638920, OPTION 3. 4/1/2014 - 3/31/2015. MULTI-ETHNIC STUDY OF ATHEROSCLEROSIS (MESA) - READING CENTER, NHLBI, MESA, G5088122703, G5108002584, G514410172, SUBCLINICAL CARDIOVASCULAR DISEASE STUDY-ULTRASOUND, G5787256936, G6095866717, G6359107525, Institute for Clinical and Translational Research, MESA, G6514094751, G66341962, MESA, G78770644, Clinical and Translational Science Award, G8761005068, Translational Training in Aging and Alzheimer’s Disease Related Disorders, G94668252, G965111525, G991334795
OpenAlex ID: W4404746061
FWCI: 1.334
Cites: 45
Cited by: 5
Related to: 10