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Human Resting-State Complexity of BOLD fMRI in Ultra-High-Field MRI at 7T: a primer

Year: 2024

Type: conference-paper

Abstract: Motivation: BOLD-fMRI intrinsic functional connectivity has limited capability to assess the temporal dynamics of complex brain networks. The insufficient signal-to-noise ratio of 3T MRI might prevent the detection of subtle alterations. Goal(s): Detecting resting-state complexity alterations in healthy subsamples using 7T MRI. Approach: Multiscale entropy was computed for ten scales from 0.1 to 1 Hz. A whole-brain ANCOVA was conducted to assess entropy differences of the scales between 30 healthy adults with spider phobia and 45 without. Results: Spider phobia showed decreased entropy in several fear-related brain regions in all scales except 1 Hz. Impact: 7T fMRI detected reduced high-frequency resting-state multiscale entropy related to spider phobia, indicating worse local processing of fear and memory-related brain regions.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2024/3450

Authors: Matthias Grieder, Kay Jann, Niklaus Denier, Werner Strik, Leila Soravia, Elisabeth Jehli

Language: English

Topic: Functional Brain Connectivity Studies

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404746073

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