Work

Improving EPI quality with GRAPPA in concurrent fMRI-fMRS at 7T

Year: 2024

Type: conference-paper

Abstract: Motivation: To develop a sequence for high-quality concurrent measurement of BOLD signal changes (fMRI) and biochemicals metabolite concentrations (fMRS). Goals: To implement parallel imaging with inline image reconstruction to improve fMRI image quality in concurrent fMRI-fMRS experiments at 7 T. Approach: We modified an fMRS-fMRI sequence to start by acquiring reference lines for GRAPPA reconstruction. Then each TR consists of a semiLASER acquisition for single-voxel MRS, and a GRAPPA-accelerated 3D EPI acquisition. Results: We obtained sufficient tSNR (30) map for the 3D EPI and a high SNR (59) and a narrow linewidth (9 Hz) for the spectrum. Impact: The modified concurrent fMRI-fMRS pulse sequence enhances the fMRI component to enable whole-brain coverage, reduced distortion, and high spatial resolution, providing a powerful tool for neuroscientists to study the dynamics of neurochemicals simultaneously with the BOLD signal.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2024/4249

Authors: Shahrokh Abbasi-Rad, Robert Frost, Nutandev Jayadev, Yulin Chang, Ovidiu Andronesi, David Norris, Zoe Kourtzi, Uzay Emir, André van der Kouwe

Language: English

Topic: Advanced MRI Techniques and Applications

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

Funders: National Institutes of Health, National Institute on Aging, National Cancer Institute, National Center for Research Resources, Eunice Kennedy Shriver National Institute of Child Health and Human Development

Awards: Fetal Neuroprotection by choline supplementation in heavy drinking pregnant women, Neuroimaging and gut microbiome markers of development in HIV-exposed uninfected infants, Sequence-universal high-frequency prospective MRI motion correction with navigators, Computeserver Structural &Functional Image Analysis, Extension of a longitudinal cognitive and brain imaging study of early-treated perinatally HIV infected children through adolescence, Center for Functional Imaging Technologies, A Storage Area Network for Structural and Functional Image Analysis, Neural correlates of in utero HIV and ART exposure: early childhood follow-up of a prospectively recruited cohort, Development of multinuclear MRI for image guided therapy of glioma patients, Development of next generation 2HG and metabolic MR imaging for precision oncology of mutant IDH and wildtype glioma patients, Robust Precision Mapping of Cortical and Subcortical Brain Metabolic Signatures in AD, Silicon Graphics Prism Extreme 128P/1TB

OpenAlex ID: W4404746109

FWCI:

Cites:

Cited by:

Related to: 10