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Longitudinal study tracking physiological changes through multiparametric MRI during repeated MRgFUS-induced BBB opening

Year: 2024

Type: conference-paper

Abstract: Motivation: Long-term delivery of therapeutic agents via repeated MRgFUS is an innovative approach for enhancing glioblastoma treatment but underlying mechanisms are not well documented. Goal(s): Find the best strategy for long-term drug delivery after multiple MRgFUS mediated BBB opening. Approach: Repeated MRgFUS treatments were delivered up to 8 sessions over one month along with a multi-parametric MRI protocol follow-up to measure physiological, hemodynamic and oxygenation parameters in order to assess the safety and effectiveness of the procedure. Results: Intensive, repeated treatments, may lead to tissue modifications that require attention and limit the frequency of ultrasound mediated drug delivery to once a week. Impact: Long-term delivery of therapeutics through a FUS-induced permeabilized BBB redefines therapeutic strategies as it improves patient outcomes. To ensure the best translation towards clinical treatment, evaluation of hemodynamics and oxygenation modifications in the CNS is necessary to refine treatment parameters.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2024/0163

Authors: Sébastien Rigollet, Thomas Ador, Erik Dumont, Chantal Pichon, Emmanuel Barbier, Anthony Delalande, Vasile Stupar

Language: English

Topic: Ultrasound and Hyperthermia Applications

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404747424

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