Work

Initial experience of combined microstructural and functional magnetic resonance imaging for the characterisation of renal tumours.

Year: 2024

Type: conference-paper

Abstract: Motivation: Accurate differentiation of renal tumour subtype and grade is not currently possible using standard of care imaging. Goal(s): To use combined functional and microstructural MRI in the form of diffusion weighted imaging with VERDICT, proton density fat fraction and hyperpolarised [1-13C]pyruvate to detect the different histological and metabolic features of different renal tumours. Two patients with histologically proven renal tumours (grade 2 clear cell and grade 3 papillary) underwent MRI imaging. Approach: Two patients with histologically proven renal tumours (grade 2 clear cell and grade 3 papillary) underwent MRI imaging. Results: Combined function and microstructural MRI differentiated tumour types and normal kidney. Impact: This study demonstrates the first combined use of VERDICT, PDFF and hyperpolarised [1-13C]pyruvate. The differentiation of renal tumours has proven difficult on imaging and this combination is a promising approach to this significant clinical problem.

Source: Proceedings on CD-ROM - International Society for Magnetic Resonance in Medicine. Scientific Meeting and Exhibition/Proceedings of the International Society for Magnetic Resonance in Medicine, Scientific Meeting and Exhibition

DOI: 10.58530/2024/2895

Authors: Richard Hesketh, Timothy Bray, Snigdha Sen, Lorna Smith, Rafat Chowdhury, Adam Retter, Lucy Caselton, David Atkinson, Eleftheria Panagiotaki, Fiona Gong, Max Bullock, Joey Clemente, Maxine Tran, Shonti Punwani

Language: English

Topic: MRI in cancer diagnosis

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W4404747777

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