Prognostic factors for patients with cancer-associated dermatomyositis: a retrospective, multicentre cohort study of 73 patients
Year: 2024
Type: article
Study design: Observational Study
Abstract: OBJECTIVES: To investigate factors associated with DM complete clinical response and overall survival with a focus on the use of immunosuppressive therapies in patients with cancer-associated DM. METHODS: We performed a multicentre, retrospective cohort study. Multivariable survival analyses used a Cox model with time-dependent covariates and adjustments with inverse probability censoring weighting. RESULTS: We included 73 patients with cancer-associated DM. Median follow-up was 3.92 years. Overall, 40 (54.8%) patients achieved cancer remission, with DM complete clinical response in 28/40 (70.0%). DM complete clinical response was associated with cancer remission (hazard ratio [HR] 2.46, 95% CI [1.13-5.32]) and younger age (HR 0.68, 95% CI [0.49-0.95]). Risk of mortality was associated with sustained cancer activity (HR 12.93, 95% CI [2.42-69.25]), male sex (HR 2.82, 95% CI [1.19-6.70]), and older age (HR 1.86, 95% CI [1.26-2.79]) but not sustained DM activity (HR 0.40, 95% CI [0.13-1.26]). Oral corticosteroid use was a protective factor only on univariate analysis (HR 0.18, 95% CI [0.08-0.42]). CONCLUSION: This study provides strong evidence of a significant association between the evolutions of DM and cancer, both in terms of overall survival and DM complete clinical response. Immunosuppressive treatments for DM were not significantly associated with mortality. TRIAL REGISTRATION: ClinicalTrials.gov, NCT04637672.
Source: Lara D. Veeken
Authors: Alexandre Teboul, Yves Allenbach, Florence Tubach, Lisa Belin, Charles Cassius, Juliette Demortier, Antoine Dossier, Caroline Faucon, Camille Kasser, Arsène Mekinian, Grégoire Monseau, Maxime Fouchard, Estel Chambrelan, Manuelle Viguier, Nicolas Kluger, Thibault Mahévas, Blanche Bergeret, Claude Bachmeyer, Cédric Lenormand, Claire Hotz, Emmanuelle Diaz, Nadège Cordel, Olivier Benveniste, Didier Bessis, Jean-David Bouaziz, François Chasset
Institutions: Inserm, Sorbonne Université, Assistance Publique – Hôpitaux de Paris, Pitié-Salpêtrière Hospital, Institut Pierre Louis d‘Épidémiologie et de Santé Publique, Hôpital Tenon, Centre de Recherche en Myologie, Université Paris Cité, Hôpital Saint-Louis, Hôpital Bichat-Claude-Bernard, Hôpital Saint-Antoine, Centre Hospitalier Universitaire de Rennes, Immuno-Régulation des Maladies Auto- immunes Inflammatoires et Cancer, Université de Reims Champagne-Ardenne, University of Helsinki, Helsinki University Hospital, Centre Hospitalier Universitaire de Nîmes, Centre de Référence des Maladies Autoinflammatoires et des Amyloses, Hôpitaux Universitaires de Strasbourg, Hôpital Civil, Strasbourg, Hôpitaux Universitaires Henri-Mondor, Centre Hospitalier Universitaire Pointe-à-Pitre, Université de Montpellier, Centre Hospitalier Universitaire de Montpellier
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404748290