Evaluation of a cervical cancer-specific restriction spectrum imaging model on an independent pilot cohort using PET/MRI: pre- and post-therapy
Year: 2024
Type: conference-paper
Abstract: Motivation: Restriction spectrum imaging (RSI) can potentially improve cervical cancer evaluation pre- and post-therapy, particularly in separating persistent malignancy from post-treatment edema. Goal(s): To evaluate a cervical cancer-specific RSI model for assessment on an independent pilot cohort examined with combined PET/MRI. Approach: Four patients underwent PET/MRI before (chemo)radiotherapy. Two of them also underwent PET/MRI within 4 weeks of treatment, MRI 3 months post-treatment and PET/MRI 6 months post-treatment. Two healthy volunteers underwent MRI only. Results: Preliminary results showed increased tumor conspicuity on RSI compared to conventional pre-therapy PET/MRI and promising results early post-therapy. Impact: Cervical cancer-specific restriction spectrum imaging (RSI), evaluated on an independent pilot cohort, indicates increased tumor conspicuity compared to conventional pre-therapy PET/MRI and promising results post-therapy. Future work will target early therapy response assessment in combined RSI-PET/MRI at a larger scale.
DOI: 10.58530/2024/0179
Authors: Elin Lundström, Ana Rodríguez-Soto, Elisabeth Hedlund, Björg Jónsdóttir, Katarzyna Kozar, Christopher Conlin, Stephane Loubrie, Stephan Jordan, Alexandra Schlein, Sheida Ebrahimi, J Stefan Peterson, Arnaud Guidon, Joshua Kuperman, Tyler Seibert, Anders Dale, Per Liss, Anthoula Koliadi, Rebecca Rakow-Penner
Language: English
Topic: MRI in cancer diagnosis
Subfield: Radiology, Nuclear Medicine and Imaging
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404748564