Work

Synthesis, cytotoxicity and molecular docking study of novel acid amine coupling derivatives

Year: 2024

Type: article

Abstract: A library of novel acid amine coupling products was synthesized and the components tested for their in vitro cytotoxicity against human breast cancer cell lines viz.MCF-7 and MDA-MB-231.One of the compounds displayed superior activity against both cell lines, with lower IC50 values compared to standard reference Doxorubicin.Two other compounds showed promising activities with encouraging IC50 values against MCF-7, and MDA-MB-231.A molecular docking study of these molecules against EGFR gave their docking scores and binding interactions, and predicted their ADME properties.

Source: ARKIVOC

DOI: 10.24820/ark.5550190.p012.315

Authors: Manisha Mummadi, Rambabu Bhukya, J. Ramchander

Institution: Osmania University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: diamond

Funder: Osmania University