Work

Expression and distribution of MUC1 in the developing and adult kidney

Year: 2024

Type: article

Abstract: MUC1 is a transmembrane glycoprotein expressed on the apical surface of polarized epithelial tissues and most carcinomas. MUC1 may play novel roles in the kidney including defense against infections. Here, we examine the expression of MUC1 in mouse and human kidneys. We show that the distal nephron and the urinary system are the predominant sites of expression of both message and protein, implicating segment-specific roles including distal nephron defense against ascending bacteria.

Source: American Journal of Physiology-Renal Physiology

DOI: 10.1152/ajprenal.00206.2024

Authors: Carlos L. Manrique-Caballero, Jonathan Barasch, Syed K. Zaidi, Carlton M. Bates, Evan C. Ray, Thomas R. Kleyman, Mohammad M. Al-Bataineh

Institutions: University of Pittsburgh, Columbia University

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases, Division of Diabetes, Endocrinology, and Metabolic Diseases, All of Us Research Program

Awards: G2376728328, G3179104213, G3358308580, G3481246373, G3520124842, G3973147738, G5417886134, G577709641, G5976658850, Regulation of K and H secretion by intercalated cells, Structure and mechanism of the protein-capture receptors of the kidney proximal tubule, G7465216548, Pittsburgh Center for Kidney Research, G7630471536, G7947658465, Leica Stellaris Confocal for Kidney Imaging Core, Role of Muc1 in the b-catenin Response to Acute Kidney Injury

OpenAlex ID: W4404751185

FWCI: 0.115

Cites: 61

Cited by: 1

Related to: 10