Work

Remote Alkynylation of Aliphatic Amines

Year: 2024

Type: article

Abstract: Advancements in transition metal catalyzed C-H activation/functionalization cascades have allowed the synthetic chemist's toolbox to be significantly expanded. Despite this, protocols for the remote alkynylation of linear aliphatic amines still remain limited. Herein, a palladium-catalyzed directing-group approach to alkynylation of aliphatic amines is disclosed. The synthetic utility was demonstrated with a gram-scale reaction and a functional group compatibility test.

Source: Organic Letters

DOI: 10.1021/acs.orglett.4c03468

Authors: Elizabeth M. Dauncey, Tom D. Sheppard, Peter D. Smith, Rachel H. Munday

Institutions: AstraZeneca (United Kingdom), University College London

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: green

Funder: AstraZeneca

OpenAlex ID: W4404753091