Next-Generation Sequencing for HLA Genotype Screening and Matching to HLA-Restricted Therapies
Year: 2024
Type: article
Abstract: This case series evaluates whether human leukocyte antigen (HLA) genotype could be inferred from standard next-generation sequencing, comparing concordance with confirmatory whole-exome sequencing and assessing if this assisted in matching patients to clinical trials.
Source: JAMA Oncology
Authors: Michael V. Gormally, Monica F. Chen, Anne Marie Noronha, Kristalla Panageas, Maggie Reynolds, Kaelyn Kohlasch, Bryan Novak, Tatiana Kee-Velez, Nikeysha Clarke, Michael Eubank, Cynthia Chu, Clare Wilhelm, Amanda Blouin, Chrisann Kyi, Claire Friedman, Charles M. Rudin, Mark G. Kris, Ronak Shah, David Aggen, Sandra D’Angelo, Alexander N. Shoushtari, Michael F. Berger, Chaitanya Bandlamudi, Christopher A. Klebanoff, Alexander Drilon, Adam J. Schoenfeld, Mark T. A. Donoghue
Institution: Memorial Sloan Kettering Cancer Center
Language: English
Topic: Genomics and Rare Diseases
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funder: National Cancer Institute
Award: Cancer Center Support Grant
OpenAlex ID: W4404755231