Viral Hepatitis in Western Patients with Advanced Intrahepatic Cholangiocarcinoma: Retrospective Assessment of Prevalence, Prognostic and Predictive Significance
Year: 2024
Type: article
Study design: Observational Study
Abstract: Despite a biologically established causative role of viral hepatitis (VH), i.e. HBV and HCV infections, on intrahepatic cholangiocarcinoma (ICC), only few large Western cohorts exploring the association between VH and ICC development are available. The prognostic significance of VH in ICC is debated, and no data are available regarding a predictive role for standard first-line CT (CT1), consisting of gemcitabine +/− platinoids. VH-positivity definition is often clinically incomplete and inconsistent among studies. Five different VH conditions, based on laboratory and anamnestic data, were investigated in a multicentric retrospective cohort of advanced ICC cases. Depending on the specific VH condition considered, 139–194 of 472 ICC cases could be categorized according to the presence of the mentioned VH conditions. VH prevalence ranged from 9.3 to 25.3%. No VH condition showed an impact on survival, although a non-significant worse outcome was observed for some HBV-related conditions. HCV-related conditions were associated to lower pre-CT1 biomarkers of inflammation, markedly higher disease control, and numerically longer time-to-progression with CT1. No benefit on time-to-progression was demonstrated for the addition of platinoids to gemcitabine in VH-positive patients (HR 0.77, CI95% 0.41–1.45), at least in HBV-related cases. These findings are clinically relevant and deserve further investigation.
Source: Cancer Investigation
Authors: Roberto Filippi, Giovanni Brandi, Andrea Casadei-Gardini, Francesco Leone, Nicola Silvestris, Maria Antonietta Satolli, Francesca Salani, Elisa Sperti, Stefania Eufemia Lutrino, Giuseppe Aprile, Daniele Santini, Mario Scartozzi, Luca Faloppi, Andrea Palloni, Marzia Deserti, Simona Tavolari, Margherita Rimini, Oronzo Brunetti, Rosella Spadi, Depetris Ilaria, Massimo Di Maio
Institutions: Azienda Ospedaliera Citta' della Salute e della Scienza di Torino, University of Turin, IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola, University of Bologna, Vita-Salute San Raffaele University, IRCCS Ospedale San Raffaele, Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele, Ospedale degli Infermi, University of Messina, University of Pisa, Scuola Superiore Sant'Anna, A. O. Ordine Mauriziano di Torino, Ospedale A. Perrino, Ospedale San Bortolo, Policlinico Umberto I, Sapienza University of Rome, University of Cagliari, Ospedale di Macerata, Istituto Tumori Bari
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W4404761907