Achievement of Clinical Remission in Life-Threatening Rosai-Dorfman Disease With Cladribine
Year: 2024
Type: article
Study design: Case Report
Abstract: Rosai-Dorfman disease (RDD) is a rare proliferative histiocytic disorder characterized by sinus histiocytosis with massive lymphadenopathy, rarely presenting with severe and life-threatening extra-nodal features. The rarity of RDD, clinically variant phenotype, limited data, and lack of a current standardized management approach make treatment decisions difficult. Herein, we present a case of life-threatening, disseminated RDD with rare clinical features of recurrent pericardial effusion, bilateral pleural effusions, and abdominal tissue fibrosis successfully treated with six cycles of cladribine, achieving clinical remission. Compilation of positive outcomes is required to establish a uniform treatment approach.
Source: Cureus
DOI: 10.7759/cureus.74576
Authors: Lex P Leonhardt, Hiroshi Yamagata, John Harcha, Alejandro Calvo
Language: English
Subfield: Physiology
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
OpenAlex ID: W4404762485