Work

Dynamic driving pressure predicts ventilator-induced lung injury in mice with and without endotoxin-induced acute lung injury

Year: 2024

Type: article

Abstract: Elastic net regression analysis of ventilation waveforms recorded during mechanical ventilation of initially healthy and lung-injured mice shows that low driving pressure is a computational biomarker associated with better ventilator-induced lung injury (VILI) outcomes and supports the use of driving pressure to guide ventilator adjustments to prevent VILI.

Source: American Journal of Physiology-Lung Cellular and Molecular Physiology

DOI: 10.1152/ajplung.00176.2024

Authors: Alison Wallbank, Alexander Sosa, Andrew Colson, Huda Farooqi, Elizabeth Kaye, Katharine Warner, David J. Albers, Peter D. Sottile, Bradford J. Smith

Institutions: University of Colorado Anschutz, University of Colorado Denver, University of Colorado System

Language: English

Topic: Respiratory Support and Mechanisms

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funders: National Institutes of Health, National Heart, Lung, and Blood Institute, U.S. National Library of Medicine

Awards: G1194287394, G1544622754, Patient Oriented Research Program in ALI/ARF, G1843961906, G2155303854, G2526997587, G4604721166, G5458489526, G5610835173, G7402481777, G9000023714, G9000077618, G9000106782, G9000249107, G9000321091

OpenAlex ID: W4404762948

FWCI: 1.775

Cites: 47

Cited by: 7

Related to: 10