Work

Development and validation of a radiomic prediction model for TACC3 expression and prognosis in non-small cell lung cancer using contrast-enhanced CT imaging

Year: 2024

Type: article

Abstract: • A radiomic model based on contrast-enhanced CT was successfully developed to predict TACC3 expression and NSCLC prognosis. • High TACC3 expression levels were associated with reduced overall survival compared to lower levels in patients with NSCLC. • The radiomic model has demonstrated strong predictive accuracy. • This study highlights the clinical significance of TACC3 as a prognostic biomarker and emphasizes the model's utility in the personalized management of NSCLC. Non-small cell lung cancer (NSCLC) prognosis remains poor despite treatment advances, and classical prognostic indicators often fall short in precision medicine. Transforming acidic coiled-coil protein-3 ( TACC3 ) has been identified as a critical factor in tumor progression and immune infiltration across cancers, including NSCLC. Predicting TACC3 expression through radiomic features may provide valuable insights into tumor biology and aid clinical decision-making. However, its predictive value in NSCLC remains unexplored. Therefore, we aimed to construct and validate a radiomic model to predict TACC3 levels and prognosis in patients with NSCLC. Genomic data and contrast-enhanced computed tomography (CT) images were sourced from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) database, and The Cancer Imaging Archive (TCIA). A total of 320 cases of lung adenocarcinoma from TCGA and 122 cases of NSCLC from GEO were used for prognostic analysis. Sixty-three cases from TCIA and GEO were included for radiomics feature extraction and model development. The radiomics model was constructed using logistic regression (LR) and support vector machine (SVM) algorithms. We predicted TACC3 expression and evaluated its correlation with NSCLC prognosis using contrast-enhanced CT-based radiomics. TACC3 expression significantly influenced NSCLC prognosis. High TACC3 levels were associated with reduced overall survival, potentially mediated by immune microenvironment and tumor progression regulation. LR and SVM algorithms achieved AUC of 0.719 and 0.724, respectively, which remained at 0.701 and 0.717 after five-fold cross-validation. Contrast-enhanced CT-based radiomics can non-invasively predict TACC3 expression and provide valuable prognostic information, contributing to personalized treatment strategies.

Source: Translational Oncology

DOI: 10.1016/j.tranon.2024.102211

Authors: Weichao Bai, Xinhan Zhao, Qian Ning

Institutions: First Affiliated Hospital of Xi'an Jiaotong University, Xi'an Jiaotong University

Language: English

Topic: Radiomics and Machine Learning in Medical Imaging

Subfield: Radiology, Nuclear Medicine and Imaging

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,130