Work

99mTc/90Y radiolabeled biodegradable gel microspheres for lung shutting fraction assessment and radioembolization in hepatocellular carcinoma theranostics

Year: 2024

Type: article

Abstract: Transarterial radioembolization (TARE) is a well-established clinical therapy for the treatment of patients with intermediate to advanced hepatocellular carcinoma (HCC) or those who are ineligible for radical treatment. However, commercialized radioactive microspheres still have some issues, such as high density, complicated preparation, non-biodegradability. Furthermore, the use of different radioactive microspheres during TARE and lung shunt fraction assessment has led to inconsistencies in biodistribution in certain cases. This study employed biodegradable hyaluronic acid (HA) as the backbone and modified with bisphosphonate and methacrylic acid to prepare biodegradable gel microspheres (HAMS) using the water-in-oil emulsification and photo-crosslinking for labeling the diagnostic radionuclide of 99m Tc and therapeutic radionuclide of 90 Y. Both 99m Tc radiolabeled HAMS ( 99m Tc-HAMS) and radiolabeled 90 Y-HAMS ( 90 Y-HAMS) were highly efficient in radiolabeling and exhibited excellent radiostability in vitro and in vivo . 99m Tc-HAMS are highly effective in assessing the LSF, while 90 Y-HAMS, administered though TARE, are effective in inhibiting the growth of in situ HCC without any side effects. Both 99m Tc-HAMS and 90 Y-HAMS have promising clinical applications in HCC theranostics.

Source: Materials Today Bio

DOI: 10.1016/j.mtbio.2024.101367