Work

Revised clinical standards for assessing sepsis: Serum iron level as an emerging biomarker

Year: 2024

Type: article

Abstract: Iron is a vital trace element for basic human and bacteria processes. Iron metabolism is altered in sepsis, decreasing iron export and increasing iron transport and cell uptake. As a defense against circulating infections, intracellular iron sequestration restricts their availability. Although iron retention has been shown to have protective effects, an upsurge in labile iron may result in oxidative injury and cell death (e.g., pyroptosis and ferroptosis) as the condition worsens. A recent meta-analysis has revealed a correlation between high serum iron levels and intensive care unit mortality. However, low serum iron levels have traditionally been associated with increased mortality rates. This letter highlights the need for further research to re-evaluate this contradictory finding and comprehend sepsis's pathophysiological mechanisms. We emphasize the need for additional knowledge to make serum iron levels a valuable prognostic and diagnostic marker.

Source: Journal of Medicine Surgery and Public Health

DOI: 10.1016/j.glmedi.2024.100161

Authors: Maham Bilal, Ali Ait Hssain, Abdulqadir J. Nashwan

Institutions: Dow University of Health Sciences, Hamad General Hospital, Hamad Medical Corporation

Language: English

Topic: Sepsis Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,850