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Piperacillin tissue concentrations in the gastrointestinal tract—a microdialysis porcine study

Year: 2024
Type: article
Abstract: • Target tissue piperacillin ƒT>MIC is significantly different in cecum and the greater omentum compared to plasma. • A piperacillin concentration of 16 µg/mL is reached within a mean time of 20 min in duodenum, cecum, the greater omentum and plasma. • Gastrointestinal tissue and plasma piperacillin concentrations are maintained above a high target of 16 µg/mL for a minimum of 199 min (44% of an 8-h dosing interval).
DOI: 10.1016/j.cpsurg.2024.101673
Authors: Louise L. Pontoppidan, Pelle Hanberg, Kim C. Houlind, Anders R. Knudsen, Jan B. Pedersen, Martin B. Knudsen, Magnus A. Hvistendahl, Mats Bue
Institutions: University of Southern Denmark, Lillebaelt Hospital, Aarhus University Hospital, Aalborg University Hospital, Regionshospitalet Viborg, Aarhus University
Language: English
Subfield: Pharmacology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $3,770
OpenAlex ID: W4404771508
FWCI: 0.478
Cites: 37
Cited by: 2
Related to: 10