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Host–Pathogen Interaction Databases: Tools for Rapid Understanding of Microbial Pathogenesis

Year: 2024

Type: article

Abstract: Understanding of microbial pathogenesis has greatly revolutionized after conventional culture-based techniques are replaced by molecular methods. This technological shift is generating huge host-pathogen interactions (HPIs) data. Moreover, computational predictions of biological interactions are also adding to HPI understanding. Recently, several dedicated databases are developed for exclusively cataloging HPIs. Present article covers about some available HPI databases, types, and evolution of this area, along with recent trends in the application of these databases for biological research. As per the recent understanding in microbial pathogenesis, HPIs are considered highly dynamic in nature with multiple outcomes, which goes beyond simple microbes-disease association. Therefore, careful cataloging of complete information about HPIs can open several avenues to understand microbial pathogenesis considering their multifaceted effects on host system. HPI databases are indispensable tools for understanding microbial pathogenesis, and this article provides comprehensive information about their uses in the field of microbial pathogenesis research.

Source: WIREs Mechanisms of Disease

DOI: 10.1002/wsbm.1654

Authors: Abdul Arif Khan, Pooja Wakchoure, Fozia Farooq, Muhammad J. A. Shiddiky, Sudhir Kumar Jain

Institutions: Indian Council of Medical Research, Vikram University, Charles Sturt University

Language: English

Topic: Bioinformatics and Genomic Networks

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: hybrid

Estimated APC paid: $4,430

Funders: Department of Science and Technology, Ministry of Science and Technology, India, Science and Engineering Research Board