Electrochemical Dual Trifluoromethylation/Cyclization of 2‐Aryl‐N‐Acryloyl Indoles Enabling Assembly of Indole[2,1‐a]isoquinolines
Year: 2024
Type: article
Abstract: An electrochemical cascade radical cyclization of 2‐aryl‐N‐acryloyl indoles with sodium trifluoromethanesulfinate as a coupling partner has been explored, which afforded the unexpected bis‐trifluoromethylated indole[2,1‐a]isoquinolines as products. Experimental results and DFT calculations disclose that this reaction involves trifluoromethylation‐triggered cyclization and the second trifluoromethylation as the key steps. This strategy does not need any transition‐metal catalysts or oxidants with a readily available trifluoromethylating reagent enabling facile synthesis of bis‐trifluoromethylated indole‐fused tricycles.
Source: Advanced Synthesis & Catalysis
Authors: Haibo Mei, Haibo Mei, Yucheng Zhang, Jiang Liu, Jorge Escorihuela, Jorge Escorihuela, Loránd Kiss, Loránd Kiss, Jianlin Han
Language: English
Subfield: Pharmaceutical Science
Domain: Life Sciences
Open Access status: green
Awards: G1772578987, G7034487035, G807016716
OpenAlex ID: W4404772532