Work

Enhanced efficacy of Magnolia denudata essential oil in fish anesthesia using nanoemulsions and self-microemulsifying drug delivery systems

Year: 2024

Type: article

Abstract: Introduction: essential oil (MDO) has emerged as a promising alternative for fish anesthesia and sedation. Methods and results: To further improve MDO anesthesia efficacy, this study developed nanoemulsion (NE) and self-microemulsifying drug delivery system (SMEDDS) formulations of MDO. Transmission electron microscopy and stability tests confirmed that both NE and SMEDDS possess smaller particle sizes and are stable under various temperature conditions. Anesthetic trials on fish demonstrated that these formulations reduced the time needed to induce anesthesia compared with the non-formulations. Additionally, physiological assessments of the fish gills showed that neither NE nor SMEDDS caused irreversible damage to respiratory function. Discussion: Overall, NE and SMEDDS present a safe and effective delivery system for MDO, enhancing its anesthetic properties while minimizing potential harm to aquatic organisms compared to traditional methods.

Source: Frontiers in Veterinary Science

DOI: 10.3389/fvets.2024.1440275

Authors: Xiangbing Zeng, Hongbiao Dong, Xiaoting Zheng, Jiasong Zhang

Institutions: Ministry of Agriculture and Rural Affairs, Chinese Academy of Fishery Sciences, Ocean University of China

Language: English

Topic: Veterinary Pharmacology and Anesthesia

Subfield: Small Animals

Field: Veterinary

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295