Work

Severe nephrotoxicity during high-dose methotrexate administration in an adolescent with acute lymphoblastic leukemia

Year: 2024

Type: article

Abstract: High-dose methotrexate is an effective and safe therapy. It is included in the treatment regimens of various hematologic and oncologic diseases. The acute and severe toxicity of this chemotherapeutic agent is unusual. Nephrotoxicity occurs in about 2-12% of patients, associated with a slow clearance of the drug. It is usually reversible but requires an early approach. The objective was to describe the case of a patient diagnosed with lymphoblastic leukemia who presented with acute kidney injury after the administration of high doses of methotrexate.

Source: Archivos Argentinos de Pediatria

DOI: 10.5546/aap.2024-10510.eng

Authors: Lucía Queizan, Luisina Peruzzo, Juan Ibañez, María S Felice

Institution: Garrahan Hospital

Language: English

Topic: Chemotherapy-induced organ toxicity mitigation

Subfield: Pathology and Forensic Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404779039

FWCI: 0.52

Cites:

Cited by: 2

Related to: 10