Asymptomatic and Mildly Symptomatic Influenza Virus Infections by Season: Case-Ascertained Household Transmission Studies, United States, 2017–2023
Year: 2024
Type: article
Study design: Observational Study
Abstract: Asymptomatic influenza virus infection occurs but may vary by factors such as age, influenza vaccination status, or influenza season. We examined the frequency of influenza virus infection and associated symptoms using data from two case-ascertained household transmission studies (conducted from 2017-2023) with prospective, systematic collection of respiratory specimens and symptoms. From the 426 influenza virus infected household contacts that met our inclusion criteria, 8% were asymptomatic, 6% had non-respiratory symptoms, 23% had acute respiratory symptoms, and 62% had influenza-like illness symptoms. Understanding the prevalence of asymptomatic and mildly symptomatic influenza cases is important for implementing effective influenza prevention strategies and enhancing the effectiveness of symptom-based surveillance systems.
Language: English
Subfield: Epidemiology
Field: Medicine
Domain: Health Sciences
Open Access status: green
Funders: Vanderbilt University, Vanderbilt Institute for Clinical and Translational Research, Marshfield Clinic Research Institute, Vanderbilt University Medical Center, Georgia Clinical and Translational Science Alliance, Moderna, Seqirus, National Institutes of Health, Centers for Disease Control and Prevention, U.S. Food and Drug Administration, Agency for Healthcare Research and Quality, National Center for Advancing Translational Sciences
Awards: G1073609984, Vanderbilt Institute for Clinical and Translational Research (VICTR), G1291463117, G1486488711, G1853596577, G2284173953, G2350500466, G4791737914, G5777075193, Mentoring in transmission of influenza and strategies for prevention, G6312763990, G6868001170, G8214155716, G872640053, G9000026873
OpenAlex ID: W4404784344