Chemical Variation and Biological Properties of the Essential Oil and Main Volatiles of Pimenta dioica Harvested in the Northern Highlands of Puebla, Mexico
Year: 2024
Type: article
Abstract: ABSTRACT The chemical variation of the annual essential oils from Pimenta dioica (PdEOs) grown in the Northern Highlands of Puebla, Mexico, and their biological activities were determined. Eugenol (>50%) and β‐myrcene (>16%) were the main volatiles contained in the annual PdEOs (2022–2024) extracted from fruit and leaves. PdEOs showed inhibitory properties on human pancreatic lipase (IC50, 33–44 µg/mL) through mixed‐type inhibition with clear eugenol involvement (IC50, 47 µg/mL). The oral administration of PdEOs and eugenol combined with corn oil on ICR mice (p < 0.01) confirmed a strong anti‐hypertriglyceridemic activity at 3 and 4.5 h post‐treatment. PdEOs showed low toxicity in 3T3 fibroblasts and probiotics (IC50 > 500 µg/mL), whereas high lethal dose in ICR mice (LD50 > 8000 mg/kg BW). Eugenol, β‐myrcene, and PdEOs decreased Helicobacter pylori viability, acting as mixed inhibitors on urease. Results of anti‐lipase and anti–H. pylori urease assays were endorsed by docking calculations.
Source: Chemistry & Biodiversity
Institutions: Universidad Politécnica Metropolitana de Puebla, Instituto Politécnico Nacional, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Benemérita Universidad Autónoma de Puebla, Benito Juárez Autonomous University of Oaxaca, Universidad Autónoma de la Ciudad de México, Secretaría de Ciencia, Humanidades, Tecnología e Innovación
Language: English
Subfield: Food Science
Domain: Life Sciences
Open Access status: bronze
OpenAlex ID: W4404789763