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Model-Based Scale-Up of a Homogeneously Catalyzed Sonogashira Coupling Reaction in a 3D Printed Continuous-Flow Reactor

Year: 2024

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide The model-based scale-up of a homogeneously catalyzed Sonogashira coupling reaction is performed in a 3D printed metal continuous-flow reactor. The reaction is monitored with inline Raman spectroscopy with a low calibration effort, applying a multivariate curve resolution approach. Manufacturing conditions result in a space time yield of 412 kg m –3 h –1 and a productivity rate of 0.078 kg h –1 .

Source: ACS Engineering Au

DOI: 10.1021/acsengineeringau.4c00027

Authors: Lisa Schulz, Norbert Kockmann, Thorsten Röder

Institutions: Technische Hochschule Mannheim, TU Dortmund University

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $3,500

Funders: BASF, Bundesministerium für Bildung und Forschung, Technische Universität Dortmund