Work

Zoonotic Potential of Chronic Wasting Disease After Adaptation in Intermediate Species

Year: 2024

Type: article

Abstract: Chronic wasting disease (CWD) is an emerging disease in Europe. We report an increase in interspecies transmission capacity and zoonotic potential of a moose CWD isolate from Europe after passage in an ovine prion protein-expressing host. Those results indicated some CWD prions could acquire enhanced zoonotic properties following adaptation in an intermediate species.

Source: Emerging infectious diseases

DOI: 10.3201/eid3012.240536

Authors: Tomás Barrio, Sylvie L. Benestad, Jean-Yves Douet, Alvina Huor, Séverine Lugan, Naïma Aron, Hervé Cassard, Juan Carlos Espinosa, Alicia Otero, Rosa Bolea, Juan María Torres, Olivier Andréoletti

Language: English

Topic: Prion Diseases and Protein Misfolding

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

Funders: European Commission, Agence Nationale de la Recherche, HORIZON EUROPE Framework Programme, Biotechnology and Biological Sciences Research Council, European Regional Development Fund, Interreg

Awards: G2260910193, Assessing and controlling the risks associated with the emergence of Chronic Wasting Disease in Europe, G2439073804, G434337789, INTERNATIONAL COORDINATION OF RESEARCH ON INFECTIOUS ANIMAL DISEASES, Ecology of Wild-life, Livestock, huMan and Infectious Diseases in changing environments, G8698621987

OpenAlex ID: W4404792173

FWCI: 0.471

Cites: 10

Cited by: 4

Related to: 10