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Ginsenoside-Re-rich ethanol extract of Panax ginseng berry enhances healthspan extension via mitostasis and NAD metabolism

Year: 2024
Type: article
Abstract: Ginseng Berry Concentrate (GBC) enhances exercise capacity in mice, but the effects of its key component, ginsenoside Re (G-Re), on aging and mitochondrial function are not well understood. This study investigates the impact of G-Re on mitophagy and its potential to promote healthy aging. Experiments in C2C12 myocytes and HeLa-mitoKeima-PARKIN cells assessed GBC and G-Re's effects on mitophagy, supported by Gene Set Enrichment Analysis. G-Re was identified as the primary component of GBC via high-performance liquid chromatography. The influence of G-Re on lifespan and healthspan was examined in Caenorhabditis elegans , with a focus on mitophagy pathways. GBC and G-Re significantly induced mitophagy and enhanced mitochondrial gene expression, improving mitochondrial function. G-Re extended lifespan and healthspan in C. elegans , effects absent in mitophagy-impaired mutants. G-Re enhances mitochondrial function and promotes healthy aging through mitophagy, suggesting its potential for mitigating age-related functional declines.
DOI: 10.1016/j.jgr.2024.11.002
Authors: Minjeong Kim, Su Hwan Kim, Juewon Kim, Eun-Ju Jin, Shibo Wei, Yunju Jo, Chang-Myung Oh, Ki-Tae Ha, Jong-Hwa Roh, Wan-Gi Kim, Donghyun Cho, Young Jin Choi, Su Myung Jung, Dongryeol Ryu
Institutions: Sungkyunkwan University, Seoul National University, Amorepacific (South Korea), Konkuk University, Gwangju Institute of Science and Technology, Pusan National University
Language: English
Open Access status: diamond
Awards: G1169668678, G1709795973, G2130741187, G2231479445, G3165649938, G3235262564, G3581582395, G5749324000, G6372046310, G6821168955
OpenAlex ID: W4404802980
FWCI: 1.04
Cites: 47
Cited by: 9
Related to: 10