Work

A Sustainable Catalyst‐Free Approach to Bipyrazoles Under Batch and Flow Chemistry Techniques

Year: 2024

Type: article

Abstract: We have developed an efficient and sustainable approach for the synthesis of 4,4′‐bipyrazole derivatives from spirocyclopropanyl‐pyrazolone and hydrazine under mild conditions. This methodology is catalyst‐free, operating effectively in both batch and continuous flow processes. The flow synthesis allows the production of products up to 110 mg/h which provides industrial applicability and scalability. Additionally, 4,4’‐bipyraole has been transformed into a triphenyl‐substituted pyrazole derivative.

Source: Asian Journal of Organic Chemistry

DOI: 10.1002/ajoc.202400583

Authors: Akanksha Kumari, Anshul Jain, Nirmal K. Rana

Institution: Indian Institute of Technology Jodhpur

Language: English

Topic: Cyclopropane Reaction Mechanisms

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Ministry of Education, India, Science and Engineering Research Board

Award: G4555977115