Work

Churg‐Strauss Syndrome: A Case of Laryngeal Presentation

Year: 2024

Type: article

Abstract: Eosinophilic granulomatosis with polyangiitis (EGPA), among various organs and systems, can affect the upper respiratory tract. The otolaryngologist must be able to suspect the pathology with the appearance of the first signs and recognize its late complications. Laryngeal involvement is rare and difficult to diagnose. A patient suffering from Churg-Strauss syndrome developed posterior glottic stenosis 5 years after diagnosis. A biopsy of the lesion confirmed the localized recurrence of EGPA. Rituximab therapy prevented further relapse after 12 months of follow-up. In the current literature, only two case reports, both pediatric, deal with laryngeal organic manifestation of the disease. Nonspecific findings, such as corditis or dysphonia, may be found in patients with EGPA in up to 25% of cases. Thus, even though primary laryngeal manifestation is rare, inflammation can be a common finding. The case herein reported appears to be the first organic Churg Strauss syndrome laryngeal manifestation in an adult patient. Laryngoscope, 135:1771-1773, 2025.

Source: The Laryngoscope

DOI: 10.1002/lary.31935

Authors: Edoardo Serafini, Margherita Basso, Massimo Lupi, Daniele Marchioni, Francesco Mattioli

Institution: Azienda Ospedaliero-Universitaria di Modena

Language: English

Topic: Vasculitis and related conditions

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,840