Work

Precision Delivery Using Nanopipette for Single-Cell Studies

Year: 2024

Type: article

Abstract: Nanopipette based scanning probe technique is a versatile tool in non-contact imaging in biology. In addition to the topographic imaging, its capability of localized delivery of bio-active molecules is emerging. In this mini review, we introduce the applications of nanopipette in single-cell researches with a focus on localized delivery. The working principles of three delivery modes including resistive pulse, pressure-driven flow, and electroosmotic flow-driven delivery are summarized and compared. Their applications in single-cell researches are reviewed. The current technical challenges in scanning ion conductance microscopy-based delivery, and their growing influence in medicine and pharmacologic researches are also discussed.

Source: Journal of Electrochemistry

DOI: 10.61558/2993-074x.3488

Authors: He Zhang, Maksudur Rahman, Yang Tao, Joseph W Sampson, Hang Ren

Institutions: The University of Texas at Austin, Texas Materials Institute

Language: English

Topic: Electrochemical Analysis and Applications

Subfield: Electrochemistry

Field: Chemistry

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: National Institute of General Medical Sciences