Preliminary evidence on the diagnostic value of apolipoprotein B and A-I in peripheral artery disease among Vietnamese patients with diabetes
Year: 2024
Type: article
Study design: Observational Study
Abstract: To evaluate the value of apolipoprotein A-I, B, and the apoB/AI ratio in the diagnostic of peripheral artery disease among patients with diabetes, we conducted a cross-sectional study of which they underwent clinical evaluation, standardized Doppler ultrasound and blood test. Area under the Receiver Operating Characteristic curve method was employed to estimate the discriminatory ability of apolipoprotein A-I, apolipoprotein B, and the ApoB/A-I ratio. A total of 159 patients were included. ApoA-I, ApoB, and the ApoB/A-I ratio show statistically significant associations with most clinical and Doppler ultrasound characteristics of PAD. In Pearson’s correlation analysis, apolipoproteins showed a stronger correlation with ABI than the traditional lipid profile. The AUROC was 0.714 (95%CI: 0.635 - 0.794); 0.300 (95%CI: 0.219 – 0.380) and 0.604 (95%CI: 0.516 – 0.692) for apoB/A-I ratio; apoAI and apoB, respectively. The probability apoB/A-I cutoff of 0.666 had a sensitivity of 0.682 and a specificity of 0.662. Apolipoprotein AI and Apolipoprotein B are tests with considerable potential in diagnosing peripheral arterial disease in patients of type 2 diabetes mellitus patients. Further studies are needed with larger sample sizes, and employing imaging diagnostic modalities with higher reliability as the gold standard (MSCT angiography).
Source: Tạp chí Nghiên cứu Y học
Authors: Nguyen Manh Ha, Nguyen Thi Ho Lan, Pham Thai Binh, Vu Minh Phuc, Hoang Van Kien, Tran Thi Nhu Quynh, Nguyen Thi Nhu Quynh, Nguyen Thi Giang, Nguyen Thi Thu, Nguyen Thi Minh Thu, Nguyen Ngoc Mai, Nguyen Thi Ngoc Hoa, Dinh Thi Thu Huong
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: bronze
OpenAlex ID: W4404830338