Work

Comparative analysis of antimicrobial resistance and genetic diversity of Bordetella bronchiseptica isolates obtained from swine within the United States

Year: 2024

Type: article

Abstract: Introduction Bordetella bronchiseptica is bacterial pathogen that is pervasive in swine populations and serves multiple roles in respiratory disease. Methods This study utilized whole-genome sequencing (WGS) analysis to assess the sequence type (ST), identify the genetic diversity of genes predicted to encode regulatory and virulence factors, and evaluated any potential antimicrobial resistance harbored by B. bronchiseptica isolates obtained from swine within the U.S. Results While a generally high degree of genomic conservation was observed among the swine B. bronchiseptica isolates, genetic diversity was identified within the fimNX locus and among the sequence type six (ST6) isolates. The majority of B. bronchiseptica isolates exhibited phenotypic resistance to four antibiotic classes, however, only three antimicrobial resistance genes were identified. Discussion Combined the data suggests that B. bronchiseptica isolates are not serving as a source of antimicrobial resistance gene transference in the swine production environment.

Source: Frontiers in Microbiology

DOI: 10.3389/fmicb.2024.1501373

Authors: Tracy L. Nicholson, Sarah M. Shore

Institutions: Agricultural Research Service, United States Department of Agriculture, National Animal Disease Center

Language: English

Topic: Microbial infections and disease research

Subfield: Microbiology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,295