Work

Synthesis, Characterization, and Investigation of Advanced Biological Properties of Non‐Ionic Group Substituted Water‐Soluble BODIPYs

Year: 2024

Type: article

Abstract: ABSTRACT In this study, glycerol, glycosyl, and tetraethyleneglycol monomethyl ether group substituted BODIPY compounds were successfully synthesized and characterized. The antioxidant, antidiabetic, antibiofilm, microbial cell viability, antimicrobial, antimicrobial photodynamic therapy, and DNA cleavage abilities of the BODIPY derivates were also tested. The highest antioxidant activity at 100 mg/L was 87.12% for BODIPY‐1, 85.61% for BODIPY‐2, and 92.78% for BODIPY‐3. The most effective inhibition of microbial cell viability was obtained for these BODIPY molecules at 100% at 50 and 100 mg/L. It was also observed that these BODIPY molecules exhibited excellent biofilm inhibition activities. The derivates were found to exhibit higher antibiofilm abilities against Staphylococcus aureus compared to Pseudomonas aeruginosa. When the antidiabetic effects of water‐soluble BODIPY compounds were examined, the highest effect was found to be 64.40% for BODIPY‐1 at 200 mg/L.

Source: Applied Organometallic Chemistry

DOI: 10.1002/aoc.7920

Authors: Lamia Sevire Sekban, Ekrem Kaplan, Sadin Özdemir, Gülşah Tollu, Esin Hamuryudan, Mukaddes Özçeşmeci

Institutions: Istanbul Technical University, Doğuş University, Mersin Üniversitesi

Language: English

Topic: Luminescence and Fluorescent Materials

Subfield: Materials Chemistry

Field: Materials Science

Domain: Physical Sciences

SDG: Good health and well-being

Open Access status: bronze

Funders: Istanbul Teknik Üniversitesi, Bilimsel Araştırma Projeleri Birimi, İstanbul Teknik Üniversitesi