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Comparative analysis of neurofilament light chain in Huntington's disease like 2 and Huntington's disease

Year: 2024
Type: article
Study design: Observational Study
Abstract: Huntington's disease-like 2 (HDL2) closely resembles Huntington's disease (HD) in clinical and pathological features. Neurofilament light chain (NfL) is an important biomarker in HD research and holds potential in HDL2. To evaluate NfL's utility in HDL2, a comparative analysis among HDL2 (n = 12), HD (n = 9), and unaffected controls (n = 9) was conducted. Employing a cross-sectional design, NfL levels were assessed in blood plasma. Concentrations were notably elevated in both HD and HDL2 groups compared to controls. HD patients displayed higher NfL levels than HDL2, possibly reflecting disease duration differences. NfL effectively distinguished HDL2 from controls, highlighting its promise as a possible biomarker in HDL2 research.
DOI: 10.1177/18796397241300141
Authors: David G Anderson, Aline Ferreira-Correia, Filipe B Rodrigues, Lauren M Byrne, Edward J Wild, Amanda Krause
Institutions: National Health Laboratory Service, University of the Witwatersrand, Queen Elizabeth University Hospital, University of Glasgow, University of Lisbon, Instituto de Medicina Molecular João Lobo Antunes, UCL Queen Square Institute of Neurology, University College London
Language: English
Open Access status: green
OpenAlex ID: W4404832823
FWCI:
Cites: 25
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Related to: 10