Year: 2024
Type: other
Abstract: Antimicrobial resistance in both veterinary and human bacterial pathogens threaten the effectiveness and access to drugs in cattle. This chapter addresses important areas of consideration in constructing antimicrobial regimens in cattle within this context, including reasonable antimicrobials for selected diseases and an extended discussion of some common therapeutic challenges. In the United States, regulations for Extra-label Drug Use (ELDU) were promulgated as directed by the Animal Medicinal Drug Use Clarification Act. Multiple antimicrobials have been evaluated in C. parvum calf disease models. Lasalocid has been used as a preventive or therapeutic agent for Cryptosporidium in calves based on anecdotal reports. Other antimicrobials such as paromomycin, azithromycin, and clarithromycin have been demonstrated to be efficacious in murine models or human therapy. Azithromycin significantly suppressed oocyst shedding and resulted in significant clinical improvement and weight gain in naturally infected calves.
Language: English
Subfield: Applied Microbiology and Biotechnology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: gold
OpenAlex ID: W4404842148