Work

A Case of Drug-Induced Lupus in Crohn’s Disease During Infliximab Therapy

Year: 2024

Type: article

Abstract: A 46-year-old man with a known case of Crohn's disease, which developed in August 2010, had been in remission since then with infliximab treatment. However, in November 2023, he developed photosensitivity, followed by joint pain and general fatigue in December. Blood tests revealed positive antinuclear antibodies, leading to a diagnosis of drug-induced lupus. After switching from infliximab to vedolizumab, his symptoms improved, and antinuclear antibodies became negative. We present a case of Crohn's disease in which drug-induced lupus developed after approximately 14 years of infliximab treatment. Cases of drug-induced lupus developing from long-term administration of tumor necrosis factor alpha (TNFα) inhibitors are rare, so we report this case with a literature review.

Source: Cureus

DOI: 10.7759/cureus.74782

Authors: Tomotaka Tanaka, Daiki Hirano, Syohei Ishimaru, Keiko Arataki

Institution: Tsuchiya General Hospital

Language: English

Topic: Systemic Lupus Erythematosus Research

Subfield: Rheumatology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W4404844675