The impact of circulating nucleosomes on inflammation in acute lung injury
Year: 2024
Type: article
Abstract: Extracellular histones are released in two major forms: free histones and nucleosomes (DNA-bound histones). However, little distinction has been made between these two forms of circulating extracellular histones. Our study detected increased circulating nucleosomes in acute lung injury patients. Further, our group identified nucleosomes as the leading form of extracellular histones compared to free histones in the plasma of COVID-19 patients, underscoring the necessity to reassess the forms of circulating histones and nucleosome contributions to immunopathology. Functionally, nucleosomes activated macrophages and induced inflammation in different organs. Mechanistically, we observed nucleosomes activating the NF-κB signaling, while inhibition of NF-κB by sulfasalazine attenuated nucleosome-induced macrophage activation. Taken together, our study indicates that extracellular histones are predominantly released as nucleosomes, playing a critical role in the inflammation of the lungs and other organs.
Source: The FASEB Journal
Language: English
Subfield: Immunology
Field: Immunology and Microbiology
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $3,560
Awards: G1470409319, G1671183399, G1673709085, G1795591630, G196810821, MMP-8 Deficiency Improves Host Responses to Influenza Viral Infections, G3040072699, Mechanistic Insights of TIMP-1 in Influenza Virus Infection, G7212831060, G7435382582, The Function and Potential Application of Extracellular Vesicle Derived Clara Cell Protein 16 in Gram-negative Bacterial Pneumonia, Emory Specialized Center of Research Excellence (SCORE) on Sex Differences, Institutional Career Development Core
OpenAlex ID: W4404852131